Author

Dean P. Edwards

Baylor College of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

Patrick R. GriffiniD· 2 shared Anna MalovannayaiD· 1 shared Antrix JainiD· 1 shared Bruce D. PascaliD· 1 shared Denis Shutin· 1 shared Josephine C. FerreoniD· 1 shared Matthew D. ManniD· 1 shared Mi Ra ChangiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Patrick R. GriffinORCID

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2 papers

Recent·Most cited

Structural proteomics defines a sequential priming mechanism for the progesterone receptor

Matthew D. Mann, Min Wang, Josephine C. Ferreon, Phoebe S. Tsoi, Michael P. Suess, Antrix Jain, Anna Malovannaya, Roberto Vera Alvarez, Bruce D. Pascal, Praveen Kumar, Dean P. Edwards, Patrick R. Griffin

This study uses structural mass spectrometry to reveal the sequential binding mechanism of progesterone receptor isoforms with co-regulatory proteins on target DNA.

Nature Communications · May 12, 2025Peer-reviewedBiochemistry

Acetylation-Primed SUMOylation Drives RORβ Turnover via a p300-SIRT1 Regulatory Axis

Timothy R. O’Leary, Denis Shutin, Nadeska I. Montalvan, Nereida M. Abad-Yang, Vuong Dang, Dean P. Edwards, Patrick R. Griffin, Mi Ra Chang

This paper identifies a post-translational regulatory axis involving p300 and SIRT1 that controls RORβ stability and transcriptional activity through acetylation and SUMOylation.

bioRxiv · Oct 30, 2024 · PreprintBiochemistry