Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes
Denise M. Drotar, Ana Karen Mojica-Avila, Drew T. Bloss, Christian M. Cohrs, Cameron T. Manson, Amanda L. Posgai, MacKenzie D. Williams, Maigan A. Brusko, Edward A. Phelps, Clive H. Wasserfall, Stephan Speier, Mark A. Atkinson
The paper examines islet and acinar cell secretion in different pancreatic regions across diabetes stages, finding reduced insulin secretion and beta-cell volume in T1D with normal enzyme secretion.
bioRxiv · Feb 8, 2024 · PreprintPathology