Stephan Speier

Villin-SNAP25 interaction regulates insulin secretion downstream of ICA512 signaling

This study shows that the Villin-SNAP25 interaction regulates insulin secretion by controlling secretory granule docking sites in response to glucose levels.

Role of GLP1-receptor signaling and α-β-cell communication in functional β-cell heterogeneity.

This study investigates how GLP-1R signaling shapes β-cell heterogeneity by analyzing calcium dynamics in islets from different mouse models and humanized KO mice.

Generation and application of novel hES cell reporter lines for the differentiation and maturation of hPS cell-derived islet-like clusters

This paper generates and validates hES cell reporter lines to monitor islet-like cluster differentiation and maturation, finding that N21 supplement improves monohormonal β-cell numbers.

Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes

The paper examines islet and acinar cell secretion in different pancreatic regions across diabetes stages, finding reduced insulin secretion and beta-cell volume in T1D with normal enzyme secretion.