Edward A. Phelps

The paper reveals that GABA secretion from pancreatic beta cells occurs via the LRRC8A/D VRAC channel and is coordinated with calcium influx and depolarization, not vesicular release or insulin secretion.

This paper develops a 3D chemotaxis chip to study NK cell migration mechanisms and finds protease-dependent migration and hyaluronic acid enhancement.

This study identifies transcriptional impairments in mitochondrial and protein homeostasis pathways in islets during type 1 diabetes pathogenesis, independent of T-cell infiltration.

This study develops a CD3-functionalized hydrogel to protect stem cell-derived beta cells from immune rejection in diabetes therapy.

This study shows that ImmTAAI, a beta cell-targeted PD-1 agonist, inhibits T cell activity in human type 1 diabetes by increasing T cell motility and reducing cytokine secretion.

This study shows that beta cell dysfunction occurs in type 1 diabetes independently of T cell infiltration, using human pancreas tissue slices from recently diagnosed patients.

This paper develops a method to efficiently transduce pancreas tissue slices with CaMPARI2 for analyzing calcium responses, finding size-dependent differences in glucose-induced activity between isolated and slice-islets.

The paper examines islet and acinar cell secretion in different pancreatic regions across diabetes stages, finding reduced insulin secretion and beta-cell volume in T1D with normal enzyme secretion.

This study shows NEGR1 promotes synaptic targeting of GAD65, affecting GABAergic signaling and feeding behavior in mice.