Author

Denise R. Smith

University of Wisconsin–Madison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Organism:yeast· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Nathaniel P. SharpiD· 2 shared Catherine M. Vickerman· 1 shared Gregory Driscoll· 1 shared Jacob Fredette-RomaniD· 1 shared Kexin Sun· 1 shared Sanad B. OmariiD· 1 shared Sterling C.T. Martin· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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2 shared papersEvolutionary Biology

Nathaniel P. SharpORCID

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2 papers

Recent·Most cited

Elevated mutation in haploid yeast driven by translesion synthesis

Jacob Fredette-Roman, Denise R. Smith, Sanad B. Omari, Nathaniel P. Sharp

The paper investigates mutation rate differences between haploid and diploid yeast by examining the role of REV1 in translesion synthesis, finding higher mutation rates in haploids and convergence after REV1 deletion.

bioRxiv · Jan 23, 2026 · PreprintEvolutionary Biology

Contribution of spontaneous mutations to quantitative and molecular variation at the highly repetitive rDNA locus in yeast

Nathaniel P. Sharp, Denise R. Smith, Gregory Driscoll, Kexin Sun, Catherine M. Vickerman, Sterling C.T. Martin

The paper quantifies mutation and selection impacts on rDNA copy number variation in yeast, finding high mutational variance and stabilizing selection.

Genome Biology and Evolution · Oct 1, 2023Peer-reviewedGenetics