Author

Jacob Fredette-Roman

University of Wisconsin–MadisonORCID 0009-0008-2008-7840Unclaimed ORCID profile · follow to get notified of new preprints

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Evolutionary Biology· 1

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Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1 Organism:yeast· 1

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Denise R. Smith· 1 shared Nathaniel P. SharpiD· 1 shared Sanad B. OmariiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperEvolutionary Biology

Denise R. Smith

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1 paper

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Evolutionary BiologybioRxivPreprintJan 23, 2026

Elevated mutation in haploid yeast driven by translesion synthesis

Jacob Fredette-Roman, Denise R. Smith, Sanad B. Omari, Nathaniel P. Sharp

The paper investigates mutation rate differences between haploid and diploid yeast by examining the role of REV1 in translesion synthesis, finding higher mutation rates in haploids and convergence after REV1 deletion.

DOI 10.64898/2026.01.22.701062

yeastDNA methylation

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