GPR17 structure and agonism with small molecules and oxysterols
Claire M. Metrick, Lu Zhang, Maria Hercher, Greg J. Dodge, Dennis Cherry, Jorge Vera Rebollar, Margot Brickelmaier, Jing Wang, Jeffrey G. Martin, Xiaoping L. Hronowski, Melissa Kemp, Andrew G. Capacci, Joseph W. Arndt, Laura F. Silvian, Karen S. Conrad, John C. Silbereis
This study presents cryo-EM structures of GPR17 with ligands and shows orthosteric and allosteric binding mechanisms, suggesting alternative approaches for drug discovery.
bioRxiv · Nov 26, 2025 · PreprintBiochemistry