Greg J. Dodge

This paper introduces a detergent exchange method to transfer membrane proteins from lipid nanoparticles to detergent micelles, preserving function and homogeneity for biochemical analysis.

This study presents cryo-EM structures of GPR17 with ligands and shows orthosteric and allosteric binding mechanisms, suggesting alternative approaches for drug discovery.

This paper develops a method to select nanobodies against membrane proteins embedded in liponanoparticles using yeast surface display, achieving high-affinity and stable Nb-protein complexes.

The paper introduces glycan analysis probes (GAPs) inspired by human lectins to study host-microbe interactions and glycan-mediated processes.

The paper identifies and validates substrate specificity of bacterial monotopic phosphoglycosyl transferases using bioinformatics and in vitro assays, supporting inhibitor discovery for antibiotic development.