Author

Laura F. Silvian

Biogen (United States)ORCID 0000-0002-5299-5201Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrew G. CapacciiD· 1 shared Claire M. MetrickiD· 1 shared Dennis Cherry· 1 shared Greg J. DodgeiD· 1 shared Jeffrey G. MartiniD· 1 shared Jing WangiD· 1 shared John C. Silbereis· 1 shared Jorge Vera RebollariD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andrew G. CapacciORCID

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1 paper

Recent·Most cited

GPR17 structure and agonism with small molecules and oxysterols

Claire M. Metrick, Lu Zhang, Maria Hercher, Greg J. Dodge, Dennis Cherry, Jorge Vera Rebollar, Margot Brickelmaier, Jing Wang, Jeffrey G. Martin, Xiaoping L. Hronowski, Melissa Kemp, Andrew G. Capacci, Joseph W. Arndt, Laura F. Silvian, Karen S. Conrad, John C. Silbereis

This study presents cryo-EM structures of GPR17 with ligands and shows orthosteric and allosteric binding mechanisms, suggesting alternative approaches for drug discovery.

bioRxiv · Nov 26, 2025 · PreprintBiochemistry