Author

Claire M. Metrick

Biogen (United States)ORCID 0000-0001-8660-5665Unclaimed ORCID profile · follow to get notified of new preprints

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrew G. CapacciiD· 1 shared Dennis Cherry· 1 shared Greg J. DodgeiD· 1 shared Jeffrey G. MartiniD· 1 shared Jing WangiD· 1 shared John C. Silbereis· 1 shared Jorge Vera RebollariD· 1 shared Joseph W. ArndtiD· 1 shared

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2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andrew G. CapacciORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintNov 26, 2025

GPR17 structure and agonism with small molecules and oxysterols

Claire M. Metrick, Lu Zhang, Maria Hercher…·John C. Silbereis

This study presents cryo-EM structures of GPR17 with ligands and shows orthosteric and allosteric binding mechanisms, suggesting alternative approaches for drug discovery.

DOI 10.1101/2025.11.26.690757

humanprotein structure

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