A DNA-scaffolded Retron Ring Mediates Antiphage Immunity
Arturo Carabias, Ruiliang Zhao, Ricardo Garcia-Martin, Nuria Ardid-Muñoz, Mario Rodríguez Mestre, Huijuan Li, Johannes Anton Kühn, Josepha Magdalene Klas, Sarah Camara-Wilpert, Dennis Zhang, Nanna Wagner, Selma Margarita Kuypers, Tillmann Pape, Søren Johannes Sørensen, Rafael Pinilla‐Redondo, Guillermo Montoya
This study defines the structure and mechanism of retron type IX, revealing how its DNA-scaffolded ring assembly mediates antiphage immunity through phage-encoded nuclease-triggered activation.
bioRxiv · Jul 14, 2026 · PreprintMicrobiology