Author

Tillmann Pape

University of CopenhagenORCID 0000-0002-0612-3568Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:bacteria (other)· 4 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2

Frequent Co-Authors

Nicholas M. I. TayloriD· 6 shared Ivo Alexander HendriksiD· 5 shared Nicholas SofosiD· 4 shared Aritz Roa-EguiaraiD· 3 shared Eva Maria SteineriD· 3 shared Leyre Marín-ArraizaiD· 3 shared Alexander HarmsiD· 2 shared Claudia S. KielkopfiD· 2 shared

Activity by Year

2023-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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Curved chords = mutual co-authorship

6 shared papersMicrobiology

Nicholas M. I. TaylorORCID

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A DNA-scaffolded Retron Ring Mediates Antiphage Immunity

Arturo Carabias, Ruiliang Zhao, Ricardo Garcia-Martin, Nuria Ardid-Muñoz, Mario Rodríguez Mestre, Huijuan Li, Johannes Anton Kühn, Josepha Magdalene Klas, Sarah Camara-Wilpert, Dennis Zhang, Nanna Wagner, Selma Margarita Kuypers, Tillmann Pape, Søren Johannes Sørensen, Rafael Pinilla‐Redondo, Guillermo Montoya

This study defines the structure and mechanism of retron type IX, revealing how its DNA-scaffolded ring assembly mediates antiphage immunity through phage-encoded nuclease-triggered activation.

bioRxiv · Jul 14, 2026 · PreprintMicrobiology

Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism

Aritz Roa-Eguiara, Leyre Marín-Arraiza, Victor Klein-Sousa, Mònica Santiveri, Nicole R. Rutbeek, Damien Piel, Tillmann Pape, Nicholas Sofos, Ivo Alexander Hendriks, Michael Lund Nielsen, Haidai Hu, Alexander Harms, Nicholas M. I. Taylor

This study resolves the structure of bacteriophage T4 at different stages, revealing mechanisms of genome delivery and superinfection exclusion.

bioRxiv · May 22, 2026 · PreprintMicrobiology

Molecular basis of the Druantia anti-phage defense system

Haidai Hu, Philipp F. Popp, Nicole R. Rutbeek, Victor Klein-Sousa, Blanca Lopez- Mendez, Aritz Roa-Eguiara, Damien Piel, Tillmann Pape, Nicholas Sofos, Ivo Alexander Hendriks, J Olsen, Inga Songailienė, Alexander Harms, Marc Erhardt, Nicholas M. I. Taylor

This study investigates the molecular mechanism of the Druantia anti-phage defense system, showing that DruH-E provides robust immunity and revealing its DNA unwinding and regulation by ATP.

bioRxiv · May 13, 2026 · PreprintMicrobiology

Structure of a novel contractile injection system in Salmonella enterica subsp. salamae

Rooshanie N. Ejaz, Kristin Funke, Claudia S. Kielkopf, Freddie J. O. Martin, Marta Šiborová, Ivo Alexander Hendriks, Nicholas Sofos, Tillmann Pape, Eva Maria Steiner, Michael Lund Nielsen, Marc Erhardt, Nicholas M. I. Taylor

The paper reports the structure of a novel contractile injection system in Salmonella enterica subsp. salamae and identifies a new CIS cluster.

Nature Communications · Apr 16, 2026Peer-reviewedMicrobiology

Structural basis for selective inhibition of human GABA transporter GAT3

Jonas Sigurd Mortensen, Francesco Bavo, Malene Hall Jensen, Alexander Peder Smiszek Pedersen, Julian Philipp Storm, Tillmann Pape, Bente Frølund, Petrine Wellendorph, Azadeh Shahsavar

This study presents cryo-EM structures of human GAT3 bound to inhibitor, substrate GABA, or in substrate-free state, revealing molecular mechanisms of inhibition and substrate recognition.

Nature Communications · Jan 29, 2026Peer-reviewedMolecular Biology

Structural characterization of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states.

Leyre Marín-Arraiza, Aritz Roa-Eguiara, Tillmann Pape, Nicholas Sofos, Ivo Alexander Hendriks, Michael Lund Nielsen, Eva Maria Steiner, Nicholas M. I. Taylor

This study presents the cryo-EM structures of PlPVC1 in extended and contracted states, revealing structural features and contraction mechanism insights.

Nature Communications · Oct 22, 2025Peer-reviewedMolecular Biology

N-terminal toxin signal peptides efficiently load therapeutics into a natural nano-injection system

Eva Maria Steiner, Rooshanie N. Ejaz, Claudia S. Kielkopf, Mar Pérez‐Ruiz, Leyre Marín-Arraiza, Ivo Alexander Hendriks, Jakob Nybo Nissen, Irina Pozdnyakova, Tillmann Pape, Alice Regaiolo, Kira Götz, Ralf Heermann, Simon Rasmussen, Michael Lund Nielsen, Nicholas M. I. Taylor

This study identifies an N-terminal signal peptide that enables efficient loading of therapeutics into the Afp nano-injection system for targeted delivery.

bioRxiv · Nov 13, 2023 · PreprintMolecular Biology

Structural and Mechanistic Basis of Substrate Transport by the Multidrug Transporter MRP4

Magnus Bloch, Isha Raj, Tillmann Pape, Nicholas M. I. Taylor

This study reports cryo-EM structures of MRP4 with various substrates, revealing molecular details of its transport mechanism and broad substrate specificity.

Structure · Sep 7, 2023Peer-reviewedMolecular Biology