Josepha Magdalene Klas

This study defines the structure and mechanism of retron type IX, revealing how its DNA-scaffolded ring assembly mediates antiphage immunity through phage-encoded nuclease-triggered activation.

The paper describes a non-canonical mechanism in Type VI retrons where reverse transcribed ssDNA derepresses translation of an antiviral toxin, providing phage defense without detectable msDNA.

This study shows that prior immunity influences tuberculosis lesion structure by modulating neutrophil and T cell responses, leading to different pathological outcomes.