Guillermo Montoya

The paper identifies the SPATA5-SPATA5L1-CINP-C1ORF109 complex as essential for pre-60S ribosome maturation and shows its evolution from yeast Drg1.

This study defines the structure and mechanism of retron type IX, revealing how its DNA-scaffolded ring assembly mediates antiphage immunity through phage-encoded nuclease-triggered activation.

This paper develops a single-domain antibody specific for M1-linked ubiquitin chains, enabling their detection and analysis across multiple applications.

This study reveals the HSP90-CDC37 chaperone system's role in RAF1 activation through pre-dimerization and asymmetric folding, showing its active regulatory role in MEK signaling and cell proliferation.

The paper describes a non-canonical mechanism in Type VI retrons where reverse transcribed ssDNA derepresses translation of an antiviral toxin, providing phage defense without detectable msDNA.

This paper identifies VCF1 as a novel p97 cofactor that enhances p97-UFD1-NPL4 interactions with ubiquitylated substrates, promoting proteasomal degradation.

The paper identifies DAXX as a novel histone chaperone pathway that deposits H3.3K9me3 before DNA deposition, expanding the histone chaperone network's role in heterochromatin assembly.

This study traces the evolutionary origin of OCT4/POU5 functions in supporting pluripotency across vertebrates using sequence analysis and functional studies in mouse ESCs.