Exploring the Role of Kv1.3 and MAPK14 in Mediating Microglial Oxidative Stress and Neuroinflammation Following Organic Dust Exposure
Nyzil Massey, Sanjana Mahadev Bhat, Denusha Shrestha, Emir Malovic, Locke A. Karriker, Shivani Choudhary, Alan Patrick Robertson, Hai Minh Nguyen, Heike Wulff, Anumantha G. Kanthasamy, Chandrashekhar Charavaryamath
This study investigates how Kv1.3 and MAPK14 contribute to microglial oxidative stress and neuroinflammation after organic dust exposure, finding that inhibiting Kv1.3 reduces inflammation and oxidative stress markers.
bioRxiv · Jan 10, 2025 · PreprintPharmacology & Toxicology