Physiological and pathological brain activation in the anesthetized rat produces hemodynamic-dependent cortical temperature increases that can confound the BOLD fMRI signal.
Sam Harris, Luke W. Boorman, Devashish Das, Aneurin J. Kennerley, Paul S. Sharp, Chris J. Martin, Peter Redgrave, Theodore H. Schwartz, Jason Berwick
The paper shows that temperature increases in anesthetized rat brains during activation can confound BOLD fMRI signals by being linked to hemoglobin changes.
Frontiers in Neuroscience · Aug 14, 2018Peer-reviewedNeuroscience