Author

Paul S. Sharp

University of Sheffield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 7

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Approach:experimental assay· 5 Organism:mouse· 5 Assay:imaging· 2 Organism:rat· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:electronic health records· 1

Frequent Co-Authors

Jason BerwickiD· 7 shared Luke W. BoormaniD· 5 shared Clare HowarthiD· 4 shared Osman ShabiriD· 4 shared Llywelyn LeeiD· 3 shared Peter RedgraveiD· 3 shared Stephen B. WhartoniD· 3 shared Aneurin J. KennerleyiD· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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7 shared papersNeuroscience

Jason BerwickORCID

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7 papers

Recent·Most cited

The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice

Beth Eyre, Kira Shaw, Paul S. Sharp, Luke W. Boorman, Llywelyn Lee, Osman Shabir, Jason Berwick, Clare Howarth

This study shows that locomotion during awake imaging alters sensory-evoked haemodynamic responses in mice, emphasizing the need to monitor movement to avoid confounding results.

Scientific Reports · Apr 14, 2022Peer-reviewedNeuroscience

Assessment of Neurovascular Coupling & Cortical Spreading Depression in Mixed Models of Atherosclerosis & Alzheimer's Disease

Osman Shabir, Ben Pendry, Llywelyn Lee, Beth Eyre, Paul S. Sharp, Monica A Rebollar, David Drew, Clare Howarth, Paul Roy Heath, Stephen B. Wharton, Sheila Francis, Jason Berwick

This study assesses neurovascular coupling and cortical spreading depression in models of atherosclerosis and Alzheimer's disease, finding exacerbated neurovascular decline and increased amyloid-beta plaques in comorbid conditions.

eLife · Dec 20, 2021Peer-reviewedNeuroscience

Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer's Disease

Osman Shabir, Paul S. Sharp, Monica A Rebollar, Luke W. Boorman, Clare Howarth, Stephen B. Wharton, Sheila Francis, Jason Berwick

The paper investigates neurovascular coupling in J20-hAPP mice under normobaric hyperoxia, finding enhanced cerebral blood volume and potential therapeutic implications for Alzheimer's disease.

Scientific Reports · May 5, 2020Peer-reviewedNeuroscience

Key aspects of neurovascular control mediated by specific populations of inhibitory cortical interneurons

Llywelyn Lee, Luke W. Boorman, Emily Glendenning, Claire R. Christmas, Paul S. Sharp, Peter Redgrave, Osman Shabir, E Bracci, Jason Berwick, Clare Howarth

The paper investigates how specific inhibitory cortical interneurons influence neurovascular coupling through optogenetic activation in mice, revealing distinct hemodynamic effects based on interneuron type.

Cerebral Cortex · Oct 8, 2019Peer-reviewedNeuroscience

The Time Course of Recognition Memory Impairment and Glial Pathology in the hApp-J20 Mouse Model of Alzheimer’s Disease

Kamar E. Ameen‐Ali, Julie E. Simpson, Stephen B. Wharton, Paul Roy Heath, Paul S. Sharp, Gaia Brezzo, Jason Berwick

This study examines recognition memory and glial pathology in hAPP-J20 mice, finding early memory impairment precedes Aβ deposition and glial activation.

Journal of Alzheimer s Disease · Feb 19, 2019Peer-reviewedNeuroscience

Physiological and pathological brain activation in the anesthetized rat produces hemodynamic-dependent cortical temperature increases that can confound the BOLD fMRI signal.

Sam Harris, Luke W. Boorman, Devashish Das, Aneurin J. Kennerley, Paul S. Sharp, Chris J. Martin, Peter Redgrave, Theodore H. Schwartz, Jason Berwick

The paper shows that temperature increases in anesthetized rat brains during activation can confound BOLD fMRI signals by being linked to hemoglobin changes.

Frontiers in Neuroscience · Aug 14, 2018Peer-reviewedNeuroscience

Seizure epicenter depth and translaminar field potential synchrony underlie complex variations in tissue oxygenation during ictal initiation.

Sam Harris, Luke W. Boorman, Aneurin J. Kennerley, Paul S. Sharp, Chris J. Martin, Peter Redgrave, Theodore H. Schwartz, Jason Berwick

The paper investigates how seizure epicenter depth and laminar synchrony affect tissue oxygenation during ictal initiation in a rat model, revealing layer-dependent hypoxia and hyperoxia patterns.

NeuroImage · Dec 30, 2017Peer-reviewedNeuroscience