Impact of Mutations Affecting 4'-Fluorouridine Susceptibility on Fitness and Treatment Outcomes for Venezuelan Equine Encephalitis Virus
Jenny Wong, Tahirah Moore, Devin Lewis, Carolin M. Lieber, Dariia Vyshenska, Elizabeth B. Sobolik, Sarah Zimmermann, George R. Painter, Richard Karl Plemper, Alexander L. Greninger, Robert M. Cox
This study identifies mutations in VEEV nsP4 that reduce susceptibility to 4-FlU, shows these mutations do not fully prevent 4-FlU's therapeutic effect in mice, and highlights its potential as an antiviral for alphavirus encephalitis.
Journal of Virology · Jan 15, 2026Peer-reviewedMicrobiology