Dariia Vyshenska

This study identifies EIDD-3525 as a broad-spectrum antiviral against alphaviruses that inhibits RNA replication by targeting the nsP4 polymerase.

This paper develops a new antiviral compound, GHP-88310, showing high tolerability and oral efficacy against measles and respiratory paramyxoviruses in animal models.

This study identifies novel small-molecule inhibitors of Chikungunya virus replication through high-throughput screening and characterizes their mechanism of action and resistance profiles.

This study identifies neutralizing epitopes on the measles virus fusion protein by analyzing monoclonal antibodies and their structural interactions with prefusion and postfusion conformations.

This study recovers Ghana virus, an African bat Henipavirus, and shows it has restricted receptor tropism and attenuated pathogenicity compared to Nipah virus.

This study identifies mutations in VEEV nsP4 that reduce susceptibility to 4-FlU, shows these mutations do not fully prevent 4-FlU's therapeutic effect in mice, and highlights its potential as an antiviral for alphavirus encephalitis.