Complementary Structural and Chemical Biology Methods Reveal the Basis for Selective Radioligand Binding to α-Synuclein in MSA Tissue
Juan C Sanchez, Ryann M. Perez, Dinahlee Saturnino Guarino, Dhruva Dhavala, Joseph K. Baumgardt, Kyle D. Shaffer, Paul T. Kotzbauer, Robert H. Mach, E. James Petersson, Elizabeth Wright
The paper uses structural and chemical biology methods to show EX-6 binds selectively to α-synuclein fibrils in MSA tissue, with a 10-fold preference over PD tissue.
bioRxiv · Jun 30, 2025 · PreprintNeuroscience