Differential disease tolerance mediates sex-biased illness severity in sepsis
Breenna Dobson, Kathryn Strayer, Ayesha Wijesinghe, Jared Schlechte, Oscar Tejada, Alexandria Bartlett, Matthew Stephens, Diana Changirwa, Nicole A. Cho, Ian-Ling Yu, Nargis Khan, B McDonald
This study shows that male-biased sepsis severity is due to impaired disease tolerance, which can be improved by mitochondrial-targeted therapy.
Proceedings of the National Academy of Sciences · Feb 24, 2026Peer-reviewedPathology