Nargis Khan

VDAC1 regulates stress-associated matrix localization of DJ-1 to support mitochondrial homeostasis and neuronal survival

This study identifies VDAC1 as a regulator of DJ-1's mitochondrial matrix localization, showing its role in maintaining mitochondrial homeostasis and neuronal survival under stress.

Differential disease tolerance mediates sex-biased illness severity in sepsis

This study shows that male-biased sepsis severity is due to impaired disease tolerance, which can be improved by mitochondrial-targeted therapy.

Neonatal BCG Vaccination Engages the Vasculature to Elicit γδ T Cell-Mediated Protection against Tuberculosis

This study shows neonatal BCG vaccination expands IL-17/IL-22-producing γδ T cells, mediates protection against TB, and induces a microbiome signature linked to gut-lung axis immunity.

β-Glucan Reprograms Neutrophils to Induce Disease Tolerance Against Influenza A Virus

This study shows β-glucan reprograms neutrophils to induce disease tolerance against Influenza A virus by promoting a unique subset of neutrophils that limit tissue damage and enhance survival.