Repurposing nystatin and taurocholate to target intracellular spore persistence during antibiotic treatment to prevent recurrent Clostridioides difficile infection.
Pablo Castro-Córdova, Maria Mendoza-Leon, A. Said Álamos-Musre, Nicolás Montes-Bravo, Juan Muñoz-Miralles, Fernando Díaz-Yáñez, Felipe M. Llancalahuén, Diego Cea, Rosario Hernández‐Armengol, Javiera Valeria Gallegos, Katherine Mondaca, Carolina Otero, F.B. Gil, Marjorie Pizarro‐Guajardo, Daniel Paredes‐Sabja
This study shows that combining nystatin, taurocholate, and antibiotics, with nanoparticle delivery, reduces recurrent Clostridioides difficile infection by targeting intracellular spores.
bioRxiv · Oct 1, 2026 · PreprintPharmacology & Toxicology