Nicolás Montes-Bravo

This study shows that combining nystatin, taurocholate, and antibiotics, with nanoparticle delivery, reduces recurrent Clostridioides difficile infection by targeting intracellular spores.

This study identifies complement proteins C1q and C3 as interacting with C. difficile spores via CdeM, influencing spore entry, persistence, and recurrence of infection.

This study identifies RECS1 as a structural component of the exosomal trafficking machinery and shows it modulates extracellular vesicle biogenesis through a channel-independent mechanism.

This study shows that C. difficile toxins TcdA and TcdB remodel fibronectin and vitronectin in intestinal tissue, enhancing spore adherence and internalization, which may contribute to disease recurrence.