Daniel Paredes‐Sabja

This study shows that combining nystatin, taurocholate, and antibiotics, with nanoparticle delivery, reduces recurrent Clostridioides difficile infection by targeting intracellular spores.

This study identifies complement proteins C1q and C3 as interacting with C. difficile spores via CdeM, influencing spore entry, persistence, and recurrence of infection.

This study characterizes the sporulation and germination of Turicibacter sanguinis, revealing unique spore architecture and regulatory mechanisms distinct from Bacilli and Clostridia.

This study analyzes the conservation and variability of BclA proteins across C. difficile clades using genomic data from over 25,000 genomes, revealing clade-specific differences in bclA gene presence and structure.

The paper isolates a hypersporulating C. difficile strain with enhanced sporulation efficiency and identifies genomic changes associated with this trait.

This study compares three spore coat and exosporium extraction methods for C. difficile spores using multiple techniques to assess their effectiveness and impact on spore structure.

This study identifies two new classical clades and two new cryptic clades in C. difficile using whole-genome analysis of 25,144 genomes.

The paper analyzes phenotypic traits of various C. difficile ribotypes to determine if core biological processes are conserved across clades, finding consistency in growth, sporulation, and bile resistance.

This study shows that C. difficile toxins TcdA and TcdB remodel fibronectin and vitronectin in intestinal tissue, enhancing spore adherence and internalization, which may contribute to disease recurrence.

FastMLST is a multi-core tool that rapidly performs MLST on draft genome assemblies, reducing processing time by 16-fold compared to existing tools.