An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4
Satarupa Bhaduri, Mac Kevin E. Braza, Stancho Stanchev, Marina Tauber, Raghad Al-Bawab, Lawrence J. Liu, Diego F. Trujillo, Kristina Solorio-Kirpichyan, Ambuj Srivastava, Javier Sanlley-Hernandez, Anthony John O’Donoghue, Marius K. Lemberg, Rommie E. Amaro, Kvido Střı́šovský, Sonya E. Neal
This study characterizes RHBDL4 enzymatic properties using an in vitro platform, identifying effective inhibitors and providing insights for drug development.
Journal of Biological Chemistry · Feb 7, 2025Peer-reviewedBiochemistry