Kristina Solorio-Kirpichyan

This study investigates how 1-deoxysphingolipids affect membrane properties and cargo trafficking in the early secretory pathway by analyzing their subcellular distribution and effects on ER membrane fluidity and ERES.

This study characterizes RHBDL4 enzymatic properties using an in vitro platform, identifying effective inhibitors and providing insights for drug development.

The paper reports a cryo-EM structure of the HRSL domain from GCN2, revealing its role in activating the kinase and regulating the ISR pathway.