Sonya E. Neal

Rhomboid protease Rhbdl2 regulates macrophage recruitment and wound regeneration in zebrafish

Loss of the rhomboid protease Rhbdl2 in zebrafish larvae speeds tail fin regrowth after injury, raises macrophage accumulation and Rac2 protein, and Rac2 knockdown reverses both effects.

Stable Hrd1 tetramers at the heart of the retrotranslocon in living cells

This study uses single-molecule imaging to show that Hrd1 forms stable tetramers in the ER, revealing a conserved hydrophobic motif critical for dislocation.

Derlin-mediated ERAD of lipid regulator ORMDL3 safeguards mitochondrial function

This study shows Derlin-mediated ERAD of ORMDL3 prevents mitochondrial dysfunction by maintaining sphingolipid homeostasis and ER-mitochondria contact sites.

1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway

This study investigates how 1-deoxysphingolipids affect membrane properties and cargo trafficking in the early secretory pathway by analyzing their subcellular distribution and effects on ER membrane fluidity and ERES.

An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4

This study characterizes RHBDL4 enzymatic properties using an in vitro platform, identifying effective inhibitors and providing insights for drug development.

Empowering STEM Students: A University-wide Mentorship Program Fostering Retention and Belonging

The paper describes a mentorship program aimed at retaining STEM students from historically excluded groups by providing mentorship, research opportunities, and professional development.