Hedgehog signaling controls cytotoxic T cell migration in the tumour microenvironment.
Chrysa Kapeni, Louise M. O’Brien, Dilyara Sabirova, Oliver M. Cast, Valentina Carbonaro, Stephen Clark-Leonard, Anne Christin Machel, Flavio Beke, Sarah McDonald, Kate M. Fife, Maike de la Roche
This study shows that Hedgehog signaling via Smo regulates CD8 T cell migration into tumors, explaining why Hh inhibitors fail in solid cancers.
Science Immunology · Jul 11, 2025Peer-reviewedImmunology