Author

Maike de la Roche

University of CambridgeORCID 0000-0002-0558-4119Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:flow cytometry· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Abdel Hamid· 1 shared Abigail R. EdwardsiD· 1 shared Alexander LairdiD· 1 shared Alisa Griffin· 1 shared Alison Fielding· 1 shared Andrew Nicholas PriestiD· 1 shared Angela Godoy· 1 shared Anna Pejnovic· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

Abdel Hamid

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3 papers

Recent·Most cited

Hedgehog signaling controls cytotoxic T cell migration in the tumour microenvironment.

Chrysa Kapeni, Louise M. O’Brien, Dilyara Sabirova, Oliver M. Cast, Valentina Carbonaro, Stephen Clark-Leonard, Anne Christin Machel, Flavio Beke, Sarah McDonald, Kate M. Fife, Maike de la Roche

This study shows that Hedgehog signaling via Smo regulates CD8 T cell migration into tumors, explaining why Hh inhibitors fail in solid cancers.

Science Immunology · Jul 11, 2025Peer-reviewedImmunology

Angiogenic and Immune Predictors of Neoadjuvant Axitinib Response in Renal Cell Carcinoma with Venous Tumour Thrombus

Rebecca Wray, Hania Paverd, Ines Prata Machado, Johanna Barbieri, Farhana Easita, Abigail R. Edwards, Ferdia Aidan Gallagher, Iosif Alexandru Mendichovszky, Thomas J. Mitchell, Maike de la Roche, Jacqueline D. Shields, Stephan Ursprung, Lauren Wallis, Anne Yvonne Warren, Sarah Joanne Welsh, , Robert J. Jones

The paper assesses neoadjuvant axitinib response in RCC with VTT using multiparametric analysis and identifies angiogenic and immune predictors of treatment response.

Nature Communications · Apr 28, 2025Peer-reviewedCancer Biology

Altered composition of the γδ T cell pool in lymph nodes during ageing enhances tumour growth

Hung-Chang Chen, Nils Eling, Celia Pilar Martinez-Jimenez, Louise McNeill O’Brien, John C. Marioni, Duncan T. Odom, Maike de la Roche

This study shows that ageing alters the composition of γδ T cells in lymph nodes, promoting tumour growth in mice.

bioRxiv · Nov 27, 2018 · PreprintImmunology