The inflammatory micro-environment induced by targeted CNS radiotherapy is underpinned by disruption of DNA methylation
Thomas O Millner, Pratistha Panday, Yu Xiao, JR Boot, James Nicholson, Z Arpe, P Stevens, Nazneen Rahman, X Zhang, Charles A. Mein, Neil D. Kitchen, Andrew W. McEvoy, Edward McKintosh, Gerald John McKenna, Dimitris Paraskevopoulos, , Silvia Marino
This study shows that targeted CNS radiotherapy disrupts DNA methylation and induces neuroinflammation through epigenetic changes in brain tissue and cerebral organoids.
bioRxiv · Mar 4, 2024 · PreprintNeuroscience