Silvia Marino

The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states

This study identifies cell state-specific regulators of glioblastoma invasion routes using single-cell transcriptomics and spatial proteomics, showing their impact on patient survival and therapeutic potential.

Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets.

The paper identifies epigenetic regulation of key pathways and novel druggable targets in glioblastoma by comparing chromatin remodelling in neoplastic and neural stem cells.

Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoids.

This study generates human cerebellar organoids to model medulloblastoma subgroups G3 and G4, showing their ability to sustain tumor growth and respond to anti-tumour compounds.

The inflammatory micro-environment induced by targeted CNS radiotherapy is underpinned by disruption of DNA methylation

This study shows that targeted CNS radiotherapy disrupts DNA methylation and induces neuroinflammation through epigenetic changes in brain tissue and cerebral organoids.