Charles A. Mein

This study profiles cell-free RNAs in prostate cancer patients on active surveillance to identify differences between stable disease and progression to radical prostatectomy.

This study shows repeated disuse atrophy creates a molecular memory in skeletal muscle, leading to transcriptional resilience in young adults but increased susceptibility in aged muscle.

This study shows that sub-chronic stress causes hypomethylation of the Fkbp5 promoter, increasing chronic pain vulnerability, but reversing this methylation does not prevent pain.

This study shows maternal rejection in owl monkeys is epigenetically transmitted and linked to altered miRNA expression across generations.

The paper identifies epigenetic regulation of key pathways and novel druggable targets in glioblastoma by comparing chromatin remodelling in neoplastic and neural stem cells.

This study shows that parental rejection in owl monkeys reduces offspring survival and alters behavior, with evidence of miRNA changes potentially linking to epigenetic transmission.

The paper uses single-cell RNA sequencing to identify distinct B cell and fibroblast populations in stricturing Crohn's disease, highlighting their potential roles in fibrosis.

This study shows that targeted CNS radiotherapy disrupts DNA methylation and induces neuroinflammation through epigenetic changes in brain tissue and cerebral organoids.

This study identifies Angiotensin II as a pro-nociceptive mediator in IBD by showing increased Agt expression and AT1 receptor activation in colonic neurons.

The paper investigates the DNA methylation profile of FKBP5 in chronic pain models, finding significant differences between pain states and correlations between CNS and blood methylation, suggesting FKBP5 as a potential biomarker for chronic pain diagnosis and vulnerability prediction.

The paper investigates transcriptome changes in human monocytes exposed to arecoline and MNPA, identifying genes linked to diabetes and obesity.

This study identifies TREM2-dependent genes and pathways in Alzheimer's disease by analyzing RNA sequencing data from brain samples, revealing its impact on microglia, oligodendrocytes, and endothelial cells.

The paper identifies age-related DNA hypermethylation at specific human tRNA gene loci using DNA methylome data from peripheral blood.

This study examines the transcriptional effects of Trem2 loss in mouse brain, revealing disruptions in cell co-expression networks and highlighting a potential role for Trem2 in endothelial cell homeostasis.