GBP1 recruitment to actin-rich pedestals induced by extracellular Gram-negative bacteria promotes pyroptosis.
Daniel J. Bennison, Ishaan Chaudhary, Dharitri Chaudhuri, Justin Chun Ngai Wong, Ayush Punwatkar, Priyanka Biswas, Miyu Stephenson, Qiyun Zhong, Wouter W. Kallemeijn, Marianne Guenot, Sandra Koigi, Diana Papp, John P Thomas, Dimple Dixit, Tamas Korcsmaros, , Avinash R. Shenoy
This study shows GBP1 is recruited to actin-rich pedestals formed by extracellular pathogens, promoting pyroptosis and IL-18 release, independent of LPS.
bioRxiv · Sep 25, 2025 · PreprintImmunology