Author

Dina De Sousa

Wellcome Centre for Cell Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Adrian Peter BirdiD· 1 shared David A. KellyiD· 1 shared Jim SelfridgeiD· 1 shared John C. ConnellyiD· 1 shared Justyna Cholewa-WaclawiD· 1 shared Kashyap ChhatbariD· 1 shared Kyla Brown· 1 shared Martha V. KoerneriD· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenetics

Adrian Peter BirdORCID

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1 paper

Recent·Most cited

Neuronal non-CG methylation is an essential target for MeCP2 function

Rebekah Tillotson, Justyna Cholewa-Waclaw, Kashyap Chhatbar, John C. Connelly, Sophie A. Kirschner, Shaun Webb, Martha V. Koerner, Jim Selfridge, David A. Kelly, Dina De Sousa, Kyla Brown, Matthew J. Lyst, Skirmantas Kriaučionis, Adrian Peter Bird

This study shows that MeCP2's binding to non-CG methylation, specifically mCAC trinucleotides, is critical for normal brain function, as demonstrated by severe Rett syndrome-like phenotypes in mice with a modified MeCP2 domain.

Molecular Cell · Feb 8, 2021Peer-reviewedGenetics