Martha V. Koerner

This study shows that MeCP2's binding to non-CG methylation, specifically mCAC trinucleotides, is critical for normal brain function, as demonstrated by severe Rett syndrome-like phenotypes in mice with a modified MeCP2 domain.

The paper investigates the molecular effects of non-canonical MeCP2 mutations in neurons and mice, finding they impact known domains rather than causing new molecular mechanisms of Rett syndrome.