Shaun Webb

This study identifies a conserved mechanism for targeted cohesin loading that organises specialised chromosomal domains in S. pombe.

The paper uses mass spectrometry to analyze histone modifications during mitotic entry, identifying three phosphorylation programs and showing H3 T3 phosphorylation marks heterochromatin, not just centromeres.

This study identifies multiple pathways in yeast that coordinate meiosis I chromosome segregation with the meiotic spindle cycle through genetic screening and functional analysis.

This study identifies RIF1's role in restoring H3K9me3 post-replication by facilitating SUV39H1, HP1, and PP1 recruitment and restraining Aurora kinase activity.

This study identifies altered metabolic, fibrotic, and splicing pathways in EDMD patients through RNA-Seq and pathway analysis, revealing subgroup distinctions and potential biomarkers.

The paper investigates whether CA repeats are primary targets of MeCP2 and finds no evidence supporting this hypothesis, instead showing they contribute modestly to MeCP2-mediated gene expression.

This study shows that MeCP2's binding to non-CG methylation, specifically mCAC trinucleotides, is critical for normal brain function, as demonstrated by severe Rett syndrome-like phenotypes in mice with a modified MeCP2 domain.

This study identifies the PRY/SPRY domain of TRIM25 as its RNA-binding region and shows its role in ubiquitination.

The paper shows MeCP2 binds to mCG and mCAC sequences in mouse brain, with binding density correlating with transcriptional regulation of neuronal genes.