Small molecule-controlled gene expression: Design of drug-like high affinity small molecule modulators of a custom-made riboswitch
Vera Hedwig, Maike Spöring, Gary E. Aspnes, Dirk Gottschling, Holger Klein, Matthias Klugmann, Sebastian Kreuz, Benjamin Ries, Gisela Schnapp, Sandra Scharsich, Jörg S. Hartig, Oliver Hucke
The paper designs a drug-like small molecule modulator of a custom riboswitch, achieving high affinity and orthogonality for gene expression control in human cells.
bioRxiv · Jan 21, 2025 · PreprintSynthetic Biology