Synthetic BiologybioRxivPreprint
Small molecule-controlled gene expression: Design of drug-like high affinity small molecule modulators of a custom-made riboswitch
Vera Hedwig, Maike Spöring, Gary E. Aspnes…·Oliver Hucke
The paper designs a drug-like small molecule modulator of a custom riboswitch, achieving high affinity and orthogonality for gene expression control in human cells.
DOI 10.1101/2025.01.21.634073