Holger Klein

The paper introduces vampW, a Bayesian method for joint variable selection in omic biomarkers and time-to-event data, showing reduced false discoveries and improved prediction.

This study identifies SP16 as a novel GIP receptor agonist that promotes lipolysis and has metabolic benefits in diet-induced obese mice.

The paper designs a drug-like small molecule modulator of a custom riboswitch, achieving high affinity and orthogonality for gene expression control in human cells.

In Silico Treatment evaluates animal models for disease relevance by simulating gene expression changes in humans, identifying suitable models and drug effects.

The paper identifies factors contributing to technical variability between bulk and single-cell RNA-seq experiments and introduces FAVSeq, a machine learning pipeline to detect these factors.