Plasminogen activator inhibitors orchestrate the immunosuppressive tumor microenvironment in pancreatic cancer
Chiara Falcomatà, Sebastian Rune Nielsen, Maximilian M. Schaefer, Bhavya Singh, Alexander Tepper, Divya Chhamalwan, Hunter T. Potak, Maxime Dhainaut, Gürkan Mollaoglu, Matthew D. Park, Miriam Mérad, Alessia Baccarini, Brian D. Brown
This study identifies Serpinb2 and Serpine1 as key factors in pancreatic cancer that remodel the tumor microenvironment to promote immune evasion and tumor progression.
bioRxiv · Jun 11, 2025 · PreprintCancer Biology