Ligand stabilization enables physiological GITR signaling and antitumor immunity
Tesfahun Dessale Admasu, Keerthi Caroline Sadanala, Dnyaneshwar Kalyane, Hongqiang Wang, Seokyoung Yoon, Woohyun Kim, Madhusudhanarao Katiki, Jeremy David Rudnick, Ramachandran Murali, John Yu
This study shows that stabilizing the GITRL ligand enhances antitumor immunity by enabling physiological signaling between APCs and T cells, unlike receptor-targeted antibodies.
bioRxiv · May 8, 2026 · PreprintCancer Biology