A TARGETED COMBINATION THERAPY ACHIEVES EFFECTIVE PANCREATIC CANCER REGRESSION AND PREVENTS TUMOR RESISTANCE
Vasiliki Liaki, Sara Barrambana, Myrto Kostopoulou, Carmen G. Lechuga, Elena Zamorano-Domínguez, Domingo Acosta, Lucía Morales-Cacho, Ruth Álvarez, Pian Sun, Blanca Rosas-Pérez, Rafael Barrero, Silvia Jiménez-Parrado, Alejandra López-García, Marta San Roman, Juan Carlos López-Gil, , Mariano Barbacid
This paper shows that combining three KRAS signaling pathway inhibitors effectively regresses pancreatic tumors and prevents resistance in preclinical models.
Proceedings of the National Academy of Sciences · Dec 2, 2025Peer-reviewedCancer Biology