Carmen E. Guerra

This study identifies a diet-imprinted macrophage-tumor circuit driven by the CAMP-P2RX7 axis that promotes pancreatic cancer initiation, plasticity, and metastasis.

This paper shows that combining three KRAS signaling pathway inhibitors effectively regresses pancreatic tumors and prevents resistance in preclinical models.

This paper develops a computational framework using single-cell whole-genome sequencing to identify ongoing chromosomal instability, showing its utility in cancer models and clinical samples.