Bivalency of natalizumab promotes inhibition of dynamic VLA-4 adhesion beyond affinity gain
Marie‐Pierre Valignat, Martine Biarnes‐Pelicot, Dominique Touchard, Audrey Rico, Patrick Chames, Olivier Théodoly, Philippe Robert
This study shows that bivalent natalizumab inhibits VLA-4 adhesion more effectively than monovalent Fab fragments under shear stress, suggesting kinetic and geometric factors are critical for therapeutic efficacy.
Integrative Biology · Jan 1, 2026Peer-reviewedImmunology