Philippe Robert

The paper investigates antibody maturation in germinal centers, finding that mechanical resistance of BCR-antigen bonds, not affinity, drives selection during maturation.

This study shows that bivalent natalizumab inhibits VLA-4 adhesion more effectively than monovalent Fab fragments under shear stress, suggesting kinetic and geometric factors are critical for therapeutic efficacy.

The paper measures cytotoxicity of bispecific antibodies using NK cells and introduces a model to decouple host response from engager characteristics.

This study measures antigen-antibody bond behavior under force using nanobodies and flow chamber assays, revealing catch bond properties and NK cell mechanosensitivity.