Martine Biarnes‐Pelicot

The paper uses single-cell RNA sequencing to analyze immune cell interactions in asymptomatic and symptomatic malaria patients, finding reduced monocyte-T cell interactions and increased inflammation in symptomatic cases.

This paper designs modular DNA-Nanobody engagers to tune T-cell immunological synapses for precision immunotherapy, showing linker-length effects on cytotoxicity and cytokine release.

The paper investigates antibody maturation in germinal centers, finding that mechanical resistance of BCR-antigen bonds, not affinity, drives selection during maturation.

This study shows that bivalent natalizumab inhibits VLA-4 adhesion more effectively than monovalent Fab fragments under shear stress, suggesting kinetic and geometric factors are critical for therapeutic efficacy.

The paper measures cytotoxicity of bispecific antibodies using NK cells and introduces a model to decouple host response from engager characteristics.

The paper uses atomic force microscopy to measure physical interactions in the hematopoietic stem cell niche, revealing differences in adhesion forces between mesenchymal stromal cells and hematopoietic stem cells.