Author

Marie‐Pierre Valignat

Centre National de la Recherche ScientifiqueORCID 0000-0002-6031-3813Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Olivier ThéodolyiD· 2 shared Audrey RicoiD· 1 shared Dominique Touchard· 1 shared Florian Dupuy· 1 shared Martine Biarnes‐PelicotiD· 1 shared Patrick ChamesiD· 1 shared Philippe RobertiD· 1 shared Pierre Bohec· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Olivier ThéodolyORCID

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2 papers

Recent·Most cited

ImmunologyIntegrative BiologyPeer-reviewedJan 1, 2026

Bivalency of natalizumab promotes inhibition of dynamic VLA-4 adhesion beyond affinity gain

Marie‐Pierre Valignat, Martine Biarnes‐Pelicot, Dominique Touchard…·Philippe Robert

This study shows that bivalent natalizumab inhibits VLA-4 adhesion more effectively than monovalent Fab fragments under shear stress, suggesting kinetic and geometric factors are critical for therapeutic efficacy.

1 citation

humanproteomics

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BiophysicsLab on a ChipPeer-reviewedJan 1, 2025

Microvalve-based devices for flow-free gradient generators

Pierre Bohec, Florian Dupuy, Victoria Tishkova…·Olivier Théodoly

This paper introduces microvalve-based devices for flow-free gradient generation, enabling precise control and automation of microfluidic experiments.

2 citations

experimental assay

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