Antagonism of kappa opioid receptors accelerates the development of L-DOPA-induced dyskinesia in a preclinical model of moderate dopamine depletion
Andrew J. Flores, Mitchell J. Bartlett, Blake T. Seaton, Grace Samtani, Morgan R. Sexauer, Nathan C. Weintraub, James R. Siegenthaler, Dong Lu, Michael L. Heien, Frank Porreca, Scott J. Sherman, Torsten Falk
This study shows that blocking kappa opioid receptors increases the rate of L-DOPA-induced dyskinesia development in a rat Parkinson's model but does not affect motor symptoms or tonic dopamine levels.
Brain Research · Dec 1, 2023Peer-reviewedNeuroscience