Author

Frank Porreca

University of ArizonaORCID 0000-0002-2267-0617Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:rat· 2 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Aubin MoutaliD· 2 shared Edita NavratilovaiD· 2 shared Harrison J. StrattoniD· 2 shared Nicolas DumaireiD· 2 shared Aida Calderón‐RiveraiD· 1 shared Andre GhettiiD· 1 shared Andrew J. FloresiD· 1 shared Blake T. SeatoniD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Aubin MoutalORCID

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4 papers

Recent·Most cited

Mechanism, and treatment of anti-CV2/CRMP5 autoimmune pain

Laurent Martin, Harrison J. Stratton, Lyuba Y. Salih, Nicolas Dumaire, Kimberly Gómez, Le-Duy Do, Santiago Loya‐López, Cheng Wu Tang, Aida Calderón‐Rivera, Dongzhi Ran, Venkatrao Nunna, Shreya Sai Bellampalli, Liberty François‐Moutal, Shizhen Luo, Frank Porreca, , Aubin Moutal

This study investigates how anti-CV2/CRMP5 autoantibodies cause pain in paraneoplastic neurological syndromes and identifies potential treatments.

Nature Communications · Aug 7, 2025Peer-reviewedNeuroscience

Antagonism of kappa opioid receptors accelerates the development of L-DOPA-induced dyskinesia in a preclinical model of moderate dopamine depletion

Andrew J. Flores, Mitchell J. Bartlett, Blake T. Seaton, Grace Samtani, Morgan R. Sexauer, Nathan C. Weintraub, James R. Siegenthaler, Dong Lu, Michael L. Heien, Frank Porreca, Scott J. Sherman, Torsten Falk

This study shows that blocking kappa opioid receptors increases the rate of L-DOPA-induced dyskinesia development in a rat Parkinson's model but does not affect motor symptoms or tonic dopamine levels.

Brain Research · Dec 1, 2023Peer-reviewedNeuroscience

Functional Sexual Dimorphism in Human Nociceptors

Harrison J. Stratton, Mahdi Dolatyarieslami, Nicolas Dumaire, Aubin Moutal, Andre Ghetti, Tamara Cotta, Stefanie Mitchell, Xu Yue, Edita Navratilova, Frank Porreca

The paper shows that female human nociceptors are sensitized by prolactin, indicating a female-selective pain mechanism.

bioRxiv · Jun 14, 2023 · PreprintNeuroscience

Neuropathic Pain Linked to Defective Dopaminergic Inhibition in Anterior Cingulate Cortex

Kevin Lançon, Edita Navratilova, Frank Porreca, Philippe Séguéla

This study shows that reduced dopaminergic inhibition in the anterior cingulate cortex contributes to neuropathic pain by increasing neuronal excitability.

bioRxiv · May 9, 2020 · PreprintNeuroscience